Abstract

NEW SPECTROPHOTOMETRIC ESTIMATION OF NORFLOXACIN IN THE TABLETS USING MIXED SOLVENCY APPROACH

Sanjay Jain*, R. K. Maheshwari, Rajesh Kumar Nema and Indrajeet Singhvi 

Abstract

Organic solvents are most frequently employed in spectrophotometric analyses. They may be sources of pollution. Some of them may be toxic while others may be costlier. Volatility may be a source of inaccuracy in spectrophotometric estimations. In the present investigation, it was proposed to solubilize Norfloxacin by use of mixed solvency concept. Norfloxacin shows maximum absorbance in the concentration range of 10-50μg/ml at 323 nm. Method of analysis has been validated for different parameters like linearity, accuracy, precision, LOD and LOQ. The percent drug estimated in tablet formulation of Batch-I and of Batch-II were 98.13±0.650 and 98.78±0.565 respectively. The range of percent recoveries varied from 96.71±0.425 to 98.38±0.776.Sodium Benzoate, Niacinamide and sodium Caprylate do not interfere above300 nm. The analytical method was found to be simple, safe (free from toxicity), economic and eco-friendly.

Keywords: Norfloxacin, UV-Spectrophotometry, solid dosage formulation, mixed solvency concept.