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Abstract

AN EMERGING CONCEPT IN ORAL DRUG DELIVERY SYSTEM: MOUTH DISSOLVING SUBLINGUAL FILMS

Shubham R. Sali*, Shital B. Gondkar and Ravindranath B. Saudagar

Abstract

Sublingual route is a very useful for rapid onset of action with better patient compliance. It provides better drug utilization and improves the efficacy of active pharmaceutical ingredients.The tablet and capsules are most popular oral solid dosage form.Many patients are difficult to swallow capsule and tablet mostly for pediatric and geriatric patients.In some cases such as sudden episode of allergic attack, motion sickness, fear of choking and an unavailability of water the swallowing of tablet and capsule is difficult. To overcome these difficulties, fast dissolving sublingual film is developed. It improves the efficacy of API’s and provides better drug utilization. The sublingual route of drug administration is very effective since the drug absorbed through the sublingual blood vessels by passes hepatic first pass metabolic process and gives a better bioavailability. The present article overviews the formulation aspects, manufacturing methods like solvent casting, evaluation parameters and applications of fast dissolving films by sublingual route.

Keywords: Fast dissolving films, Mouth dissolving films, Self-micro-emulsifying mouth dissolving film and Application, Sublingual films.


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