Abstract

PHYTOCHEMICAL SCREENING AND TOXICOLOGICAL STUDY OF AQUEOUS AND ETHANOLIC EXTRACTS OF ENTADA MANNII (FABACEAE)

Kassi Bosson Jean Aristide Jacob, Doumbia Idrissa*, Coulibaly Adama, Kipré Gueyraud Rolland, N'guessan Jean David and Djaman Allico Joseph

Abstract

This study aimed to evaluate the acute toxicity and to carry out the phytochemical study of aqueous and ethanolic extracts of Entada mannii (Fabaceae) a plant used in the traditional treatment of diabetes in the south-east of Cote d'Ivoire. The various tests carried out in the context of phytochemical screening was oriented towards the identification of the main chemical groups. To evaluate the toxicity, 60 wistar rats were divided into twenty groups containing three animals in each group. Mortality was observed after 24 hours while animal aspect and behavior changes were noted for 14 days. The acute toxicity study indicates that the extracts of Entada mannii (Fabaceae) have no toxicity at a dose of 5000 mg / kg. The phytochemical screening of 2 extracts revealed the following main groups: sterols, polyterpenes, polyphenols, flavonoids, alkaloids, saponosides.

Keywords: Entada mannii, acute toxicity, rats, phytochemical screening.