Abstract

ULTRA-SENSITIVE SPECTROPHOTOMETRIC DETECTION OF BREAST CANCER THERAPY ANASTROZOLE USING CARBON QUANTUM DOTS/SILVER NANOCOMPOSITE

Abdulkareem Abdulraheem, Maha F. El-Tohamy*, Nabeel Alsaffar, Maryam Al Hussaini

Abstract

The present study focused on the employment of carbon quantum dots decorated silver nanocomposite (CDQs/Ag) for the detection of breast cancer therapy, anastrozole (ATZ). A green synthesis of glucosederived CQDs was conducted using a facile microwave-assisted method. Due to the unique interaction of the investigated drug and the as-prepared sensing solution, the color intensities were increased as a function of ATZ concentrations. The suggested method displayed a linear relationship over a concentration range of 5-80 μg mL-1 at a wavelength of 224 nm. The lower limit of detection was 2 μg mL-1 and the quantification detection limit is 5 μg mL-1. The proposed CQDs/Ag nanocomposite method provides a promising tool for the detection of ATZ in bulk and pharmaceutical formulations.

Keywords: Anastrozole, Carbon Quantum Dots, Silver Nanoparticles, Spectrophotometry, Cancer Therapy.