Abstract

DEVELOPMENT OF SOLID SELF-EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW

Nhat Minh Nguyen, Van Quynh Luu, Anh Thi Pham and Bo Wang*

Abstract

Self-emulsifying drug delivery system (SEDDS) is one of the most popular and commercially viable formulation approaches to improve solubility of water-insoluble drugs. However, SEDDS are normally prepared as the liquid form that has several limitations. SEDDS is converted into solid self-emulsifying drug delivery systems (SSEDDS) by solidification technique, which maintains the advantages of L-SEDDS whilst enhancing storage stability. Thus the aim of this review is to discuss solid carriers, various methods of preparation and the stability of S-SEDDS for providing more options for future drug research.

Keywords: solid self-emulsifying drug delivery systems, SSEDDS, method, stability.