Abstract

PHARMACOLOGICAL EVALUATION OF GLIMEPIRIDE FOR DIABETES MELLITUS AND ASSOCIATED COMPLICATION IN RATS

Md. Akram Minhaj*, Shalini Chawla, Vaishali Baba Saheb Lote and Anil Ahuja

Abstract

Present study is designed to evaluate the possible involvement of glimepiride in complication of diabetes mellitus in wistar rats.3 groups of rats with 6 rats per group were taken in the study. Diabetes was induced with high fat diet for 63 days. Glimepiride was given in a dose of 17.5 mg/kg for 90 day.5 parameter viz Post Prandial blood sugar, Uric acid, C-peptide, Micro RNA 21 and total Protein were investigated.Complication of diabetes in a form of diabetic nephropathy was seen in the animal and it was correlated to the parameter taken in the study. Finally it was concluded that the glimepiride indirectly involved in diabetic nephropathy apart from its existing pharmacological role. Micro RNA expression performed in the present study also favors the occurrence of complication of diabetes in glimepiride treated groups of rats.

Keywords: Glimepiride, Diabetes mellitus, Micro RNA, Protein.