Abstract

IN-VITRO EVALUATION OF ANTIULCER ACTIVITY OF MELIA AZEDARACH LINN LEAVES ON WISTAR ALBINO RATS

Dr. Nandu Kayande*, Tushar Mahajan, Rahul Sisodiya and Gourav Barathe

Abstract

Peptic ulcer disease (PUD) is considered as one of the common diseases in the world. Treatment of peptic ulcer with synthetic drugs such as proton pump inhibitors, H2 receptor antagonists and other nonsteroidal anti-inflammatory drugs has shown adverse effects, relapses, drug interactions. Medicinal plants containing active chemical constituents are useful in prevention and treatment of various diseases. The present study shows the Melia azedarach Linn leaves have very good effect on pH of Gastric Contents. It lowers down the gastric content as compared to standard omeprazole. It is also shows the lowering ulcer index.

Keywords: Peptic ulcer, Proton pump inhibitors, Ulcer Index, Omeprazole.