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Abstract

CURRENT STATUS OF ORALLY DISINTEGRATING DRUG DELIVERY SYSTEM AND FUTURE PROSPECTS

Sachin B. Dudhe, Pravin K. Bhoyar, Mangesh H. Hingankar, Upadesh B. Lade

Abstract

Over the past three decades, Orally Disintegrating Tablet (ODT) has gained much attention as a preferred alternative to conventional oral dosage form such as tablet and capsules. This are also called as orodisperse, mouth dissolving, rapidly disintegrating, and fast melt system. This disintegrates in the mouth in seconds without chewing and the need of water which is advantageous mainly for pediatrics, geriatrics and patients having difficulty in swallowing tablets and capsules. Conventional preparation methods are spray drying, freeze drying, direct compression, Molding, and sublimation while new technologies have been developed for the production of orodispersible tablets. This review describes various formulation aspects, disintegrants employed and challenges in formulating ODTS, along with various exipients, evaluation tests and industrial applications in detail.

Keywords: Orally disintegrating tablet; Super-disintegrant; Orodispersible tablets; Evaluation technique.


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