Abstract

APPROCHES OF ENHANCE TRANSDERMAL DELIVERY OF ROPINIROLE HCL

G. Koteshwarrao*, Shravan Kumar Dholi and Sridhar Vanga

Abstract

The present study was to study the approaches to enhance the transdermal delivery of Ropinirole hcl. Chemical approach is one of the approach to increase the permeation of drug. Transdermal patches are prepared with HPMC E-15 with other combination of polymers like Ethyl cellulose, PVA, PVP K-30 and Propylene glycol used as permeation enhancer. The formulation (F11) containing HPMC E15 1500mg, Ethyl cellulose 500mg chooses to study the effect of different types of permeation enhancers(viz. ; Linseed oil, Olive oil, Oleic acid, Urea, Menthol and Camphor) as it shows controlled drug release manner. The in-vitro diffusion studies showed that, compare to other permeation enhancers Menthol and Camphor shows highest drug release 92.13±0.84 %, 94.48±0.68% respectively with 10% concentration. The order of permeation effect of the permeation enhancers in 1% and 5% concentrations is Linseed oil < Olive oil < Oleic acid < Urea < Menthol< Camphor. The ex-vivo studies are conducted to formulation F11 and, the results are 58.28±1.89% and 94.87±1.98% respectively. This study requires further investigations like in-vivo and human trials for therapatic utility.

Keywords: Chemical approach, Ropinirole hcl, Fatty oils, Terpenes, Urea.