Abstract

DEVELOPMENT AND EVALUATION OF METOPROLOL SUCCINATE LOADED SUPERPOROUS HYDROGEL IN A CAPSULE: AS A GASTRORETENTIVE DRUG DELIVERY DEVICE

Kauser Fatema*, Dr. S. R. Shahi, Tauqeer Shaikh, Sana Kausar Shaikh

Abstract

The present study aims to develop a gatroretentive drug delivery device of metoprolol succinate (M.S) loaded superporous hydrogel (S.P.H) in a capsule. Swelling ratio, apparent density, drug content, and drug release in 0.1N HCL were evaluated for these M.S loaded S.P.H. Hydroxy propylmethyl cellulose is used to form a gel barrier around superporous hydrogel and helps to retard drug release for 12h. A 32 factorial design was applied for optimization purpose. D.S.C result shows no interaction between superporous hydrogel forming polymers and the drug. M.S. Stability data shows no comparable differences in physical parameters and the drug release after 3 months of accelerated stability study. ANOVA for Response Surface shows The "Pred R-Squared" of 0.9878 is in reasonable agreement with the "Adj RSquared" of 0.9975.Hence, the developed M.S loaded superporous hydrogel (S.P.H) in a capsule of improved efficacy can perform better therapeutically.

Keywords: Metoprolol succinate, gatroretentive drug delivery device, superporous hydrogel, capsule, surface response methodology.