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Abstract

DEVELOPMENT OF NEW VALIDATED ANALYTICAL METHODS FOR THE ESTIMATION OF BOSENTAN IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV SPECTROPHOTOMETRY

Mastanamma Shaik, Pasupuleti Saidulu, I.S.Tejaswini. U . Annapurna

Abstract

The present study describes a simple, accurate, precise, specific and highly sensitive methods for the determination of Bosentan present in pharmaceutical dosage forms. Bosentan exhibits maximum absorbance (λ max) at 269 nm (Method A) and Method B is an area under curve(AUC)method 264-274nm.The drug obeys the Beer- Lambert’s law in the concentration range of 2.5-15 μg/ml in two methods. The methods were validated and can be successfully applied to estimate Bosentan in pharmaceutical dosage forms. The proposed methods were validated in terms of linearity, precision and accuracy the present work provides an accurate and sensitive method for the analysis of Bosentan in bulk and tablet formulation.

Keywords: Bosentan , UV-Vis Spectrophotometry, AUC, tablets.


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