SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL, ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL MANNICH BASES OF BENZIMIDAZOLE DERIVATIVES
Abhay Kumar Verma*, Rashmi kumari, Arun Kumar Singh (Sr.), B.Nagaraju, Mukesh Chandra Sharma
Abstract
A new series of novel Mannich bases of benzimidazole were
synthesized by condensation of substituted secondary amines and
aldehyde in ethanol. These compounds were identified on the basis of
melting point range, Rf values, elemental analysis, UV, IR and 1H
NMR spectral analysis. The compounds were evaluated for
antimicrobial, analgesic and anti-inflammatory activities. All
compounds exhibited significant to moderate biological activity.
Keywords: Mannich base, Benzimidazole, Antimicrobial, Analgesic, Anti-inflammtory.
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