Abstract

SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT OF OLMESARTAN MEDOXOMIL BY SOLID DISPERSION AND DEVELOPMENT OF ORALLY DISINTEGRATING TABLETS

Ashok M. Khandekar, Kishorkumar B. Burade, Sagar J. Kanase, Ganesh R. Sawant, Devidas S.Narute, Suresh B.Sirsath

Abstract

The main objective of the research work is to improve the solubility and dissolution rate of olmesartan medoxomil by solid dispersion with carriers like PVPK30,PEG6000 and sodium lauryl sulfate.The solid dispersion were prepared by kneading method. The prepared solid dispersion were characterized by Fourier Transform Infrared Spectroscopy (FTIR), X-RayDiffraction (XRD) and Differential Scanning Calorimetry (DSC). The FTIR and XRD spectra of olmesartan/carriers solid complexes showed that olmesartan medoxomil could form complex with carriers in solid state. The XRD spectra of olmesartan/ carriers solid complexes indicated olmesartan medoxomil existed in amorphous state, this could be explained the fact that the aqueous solubility of olmesartan medoxomil was increased. From the prepared solid dispersion, orally disintegrating tablets were formulated by using various superdisintegrants like sodium starch glycolate and croscarmellose sodium in various concentrations (5- 15%).Prepared tablets were evaluated for physical parameters and drug release by invitro dissolution studies. Dissolution studies showed fast release of olmesartan medoxomil in tablets containing a high level of crosscarmellose sodium. Complexation of olmesartan medoxomil with carriers significantly improved the solubility of the drug and improved the mechanical properties of tablets produced by direct compression.

Keywords: Olmesartan Medoxomil Carriers, Sodium Starch Glycolate, Croscarmellose Sodium, Orally Disintegrating Tablets.