Abstract

A SHORT REVIEW ON SYNTHESIS AND ITS MEDICINAL SIGNIFICANCE OF 1, 3 BENZOTHIAZOLE DERIVATIVES

Midhula C. C.*, Akash Marathakam, Baijika P and Shadiha Saheed K.

Abstract

Benzothiazole nucleus plays an important role in heterocyclic chemistry due to its structural simplicity. A series of benzothiazole and its related products were synthesised by using different methods and evaluated for its biological activity. It remains one of the most typically studied heterocyclic compounds due to its wide range of pharmacological activities such as anticancer, antimicrobial, antifungal, antibacterial, anticonvulsant, anthelmintic, anti-tubercular, anti-inflammatory, antioxidant and anti-diabetic activities. Works of the literature shown that structural modification of benzothiazole derivatives have enhanced its biological activities and increased a great interest in the research field. The present review focuses on the synthesis of benzothiazoles derivatives with potential activities.

Keywords: Heterocyclic compounds, Benzothiazole, Synthesis, Biological activities.