WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

PREPARATION AND CHARACTERIZATION OF SOLID DISPERSION OF FUROSEMIDE

Purohit Nimesh Bhikhabhai

Abstract

The purpose of this study was to develop solid dispersion(SD) tablets of furosemide. Furosemide is poorly water soluble, anti-hypertensive and diuretic drug mainly used in hypertension and pulmonary edema.The crucial aspect in the preparation of SD of furosemide is to improve solubility of furosemide.The SD prepared by two methods using Physical mixing and Solvent evaporation method using four polymers PEG4000, PEG6000, PEG8000 and Poloxamer407 using different drug carrier ratios such as 1:1, 1:3, and 1:5. The prepared solid dispersion is characterized by solubility test, FT-IR spectroscopy, DSC study, X-ray diffraction. A successful increase in solubility of furosemide is obtained by preparing SDs. SD with Poloxamer407 with solvent evaporation method using drug carrier ratio 1:3 shows highest improvement in solubility than others. But the SD formulation is not convenient to take patient orally. So to ease of patient the tablets of SD is prepared using direct compression method. In the In-vitro drug release evaluation of SD tablets it also shows that the highest 97.41% drug release given by SD tablet containing Poloxamer407 with drug carrier ratio 1:3. This best formulation is compared with marketed conventional tablet of furosemide and charged for Stability study.By preparing SD of furosemide the enhancement of solubility can be achieved and solvent evaporation method is better than physical mixing can be concluded.

Keywords: Solid dispersion, Furosemide, Physical mixing, Solvent evaporation, Solubility.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More