Abstract

NIMESULIDE INDUCED CONCURRENT LEUKOCYTOCLASTIC VASCULITIS AND HEPATITIS - CASE REPORT

Shubham Prasad, Priyanka Singh, Lalit P. Meena*, Jaya Chakravarty, Madhukar Rai and Shyam Sundar

Abstract

Nimesulide is a relatively cox-2 selective non-steroidal antiinflammatory drug [NSAID] which has been already subjected to many controversies in the past. Many adverse drug reactions [ADR] have been attributed to this drug due to which it has already been banned in developed nations of world. Nimesulide is still easily available in developing countries including India. Although association of cutaneous vasculitis and hepatitis with nimesulide is well known separately. But there have been very few case reports in literature describing concurrent development of both hepatitis and cutaneous vasculitis with this drug. With this background we are reporting from tertiary care centre of north India a case of concurrent hepatitis and LCV with use of nimesulide. This case adds to the fact that, like developed nations, India and other third world countries should also ban use of nimesulide in all age groups.

Keywords: Nimesulide, Vasculitis, Drug Reaction.