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Abstract

NEW ANDROGRAPHOLIDE DERIVATIVES AND THEIR CYTOTOXIC ACTIVITY

S. Vijay Kumar, P. Swapna, P. Venkat Reddy, Ravindra Patil

Abstract

A new series of sulfonyl-type of andrographolide derivatives were synthesized from andrographolide, the cytotoxic constituent of the plant Andrographis paniculata. The derived analogs (4a-4g) were evaluated for their cytotoxic activity against human small lung cancer (NCI-H187), leukemia K562, breast cancer (MCF-7/ADR) and lung adenocarcinoma (A549) cell lines. Most of the analogues show significant cytotoxic activity against tested cell lines. The methyl sulfonyl derivative 4a had higher activity than parent compound andrographolide 1, and reduced activity than standard drug cisplatin against tested cell lines.

Keywords: Andrographolide, Andrographispaniculata, cytotoxic activity, sulfonyl type of analogues.


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