Abstract

A KINETIC STUDY OF OXIDATION OF DOMPERIDONE BY POTASSIUM DICHROMATE IN ACID MEDIUM

Syed Yousuf Hussain*, Sayyed Hussain, Mazahar Farooqui and Sayyed Salim

Abstract

Kinetics of oxidation of domperidone using potassium dichromate as oxidizing agent in acid medium was studied spectrophotometrically at 520 nm. The result interprets that rate of oxidation is first order with respect to potassium dichromate and domperidone where as it does not depend on the concentration of acid. The stoichiometry of the reaction was found that one mole of oxidant is consumed for oxidation of three moles of domperidone and the product found is domperidone N-oxide. From the results of kinetic studies, reaction stoichiometry and product analysis with suitable mechanism of the reaction was proposed. Based on results of the reaction at different temperatures, the activation parameters with respect to the slow step of the proposed mechanism was calculated.

Keywords: Kinetics, Oxidation, Domperidone, Potassium Dichromate.