Abstract

FORMULATION, DEVELOPMENT AND IN VITRO EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF CANDESARTAN CILEXETIL FOR CARDIOVASCULAR DISEASES

S R Kawathe, K S Salunkhe, S R Chaudhari, M H Harwalkar

Abstract

The chronomodulated drug delivery system is widely used for treatment of diseases occurs due to circadian changes in the body the body. This system is aims to release drugs at a programmed pattern i.e.at appropriate time and/or at appropriate site of action. In this research, formulation developed for the chronotherapy of cardiovascular diseases to treat high blood pressure early in the morning. For that purpose the compression coated tablet of candesartan cilexetil was prepared by using different coating polymers like hydroxy propyl methyl cellulose K4M, Eudragit L100-55 and Eudragit S100. These polymers were gives the pulsatile drug delivery from the formulation.

Keywords: Pulsatile drug delivery system, Candesartan cilexetil, HPMC K4M, Eudragit L100-55, Eudragit S100, Compression coating.