ANTIMICROBIAL AND ANTIMALARIAL EVALUATION OF SOME NOVEL 2,3-DIHYDRO-4-METHYL-2-THIOXO-1H-IMIDAZOL-5- YL)ETHANONE
Ram Kishore* and Monika Kamboj
Abstract
Novel cyclic thio-urea(aryl or hetero aryl) substituted 2,3-dihydro-4-
methyl-2-thioxo-1H-imidazol-5-yl)ethanone derivatives have been
synthesized by the amine, CS2 and aqueous NH3, Triton-B and 3-
chloro-2,4-pentanedione. These were screened for in-vitro
antimicrobial activity against two gram positive (Streptococcus
pyogenes and Staphylococcus aureus) and two gram negative bacteria
(Pseudomonas aeruginosa and Escherichia coli) as well as for
antifungal and antimalarial activity against Plasmodium falciparum
strain. Compound 3(d) and 3(g) exhibited good antimicrobial and
antimalarial activity.
Keywords: 3-chloro-2,4-pentanedione, amine, CS2, aqueous NH3, catalyst (trimethyl benzyl ammonium hydroxide)Triton-B, Antimicrobial and antimalarial activity.
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