Abstract

SIGNIFICANCE OF NANOPARTICLE DRUG DELIVERY SYSTEM THAN CONVENTIONAL DRUG DELIVERY SYSTEM OF ANTIHYPERTEENSIVE DRUGS

Dr. Sabeel Marangattu Moideen, Dr. S.Kuppuswamy

Abstract

The main obstacles for the oral delivery of antihypertensive drugs are low bioavailability and its instability problems. Nanoparticles protect the labile drugs against the GIT harsh environment. Nanoparticles are defined as particulate dispersions or solid particles with a size in the range of 10-1000 nm. Nanoparticles are sub-nano sized colloidal structures composed of synthetic or semi synthetic polymers.11 Polymeric nanoparticles have been extensively studied because of their unique and valuable physicochemical and biological properties. Indeed nanoparticles can protect the drug from degradation, enhance its transport and prolong its release; therefore they may improve the plasma half life of the drug. The nanoparticle preparations represent sustained release forms with increased bioavailability, a less pronounced initial antihypertensive effect and a long-lasting action with a good stability.

Keywords: nanoparticles, antihypertensive drugs.