Abstract

CHEMOPREVENTIVE EFFECTS OF PHENETHYL ISOTHIOCYANATE IN A GRAPHENE OXIDE BASED NANOCOMPOSITE AGAINST HUMAN LUNG, BREAST AND COLON CANCER CELL LINES

Dasan Mary Jaya Seema, Bullo Saifullah, Mariadoss Selvanayagam*, Mohd Zobir Hussein, S. Suresh Kumar and Palanisamy Arulselvan

Abstract

Nanocomposites are on the trials in research to be used as potential carriers of anticancer compounds. In this study, graphene oxide (GO) was used as the nanocomposite carrier of tested anticancer compound phenethyl isothiocyanate (PEITC). The objective of this research is to evaluate the chemopreventive effects of designed nanocomposite GOPEITC on human lung, breast and colon cancer cell lines. The formulated nanocomposite drug (GO-PEITC) along with the pure compound PEITC, and GO were tested on the cell viability of A549 (Lung cancer cells), MCF-7 (Breast cancer cells), and HT-29 (Colon cancer cells) for 72 hours in increasing concentrations (0 – 10 μg/ml). The results showed chemopreventive effects of the formulated nanocomposite (GO-PEITC) on all three human cancer cell lines in an increasing dose pattern. It was clear from the results that the nanocomposite drug has better anti-cancer effects on the cancer cells as compared to the pure drug (PEITC). Therefore, this research can be used as a baseline to develop PEITC as a GO-based nanocomposite drug with strong chemopreventive properties for cancer treatment upon conducting thorough pre-clinical and clinical trials.

Keywords: Phenethyl isothiocyanate, graphene oxide, chemopreventive, nanocomposite, drug nanocarrier.