Abstract

CHANGES IN BLOOD PARAMETERS AND IRON STATUS OF OSTEOPOROSIS WOMEN IN BASRA PROVINCE / IRAQ

Mustafa Abd-Almajeed Hussein* and Sami Jiber AL-Maliki

Abstract

Osteoporosis is characterized by low bone mass, deterioration of bone tissue and disruption of bone architecture, compromised bone strength and an increase in the risk of fracture. Blood have different function and play an important role in hematopoietic stem cell and recently, it has been proposed that human osteoblasts support the growth of primitive human hematopoietic cells in vitro and possibly in vivo. Iron intake was associated with BMD in healthy postmenopausal women, while the iron deficiency lead to decreased bone mineral density (BMD) and mechanical strength in osteoporosis women. hemoglobin levels/anemia showed significant associations with total bone density, also level of ferritin was affected by the iron metabolism in humans body. Fifty six women patients aging between (60-69) years old visit a clinic in Ibnalbitar private hospital to determine the percentage of bone density by measuring the bone mineral density of lumber spine and hip by a dual energy x-ray absorptiometry (DEXA) from Lunar Prodigy (version 16) (USA). This women are referring from Basra province. After diagnosis of disease by using DEXA machine, blood sample was taken from each patient, then the blood parameters include RBC, WBC, Hb, PCV was measured by Auto Hematology Analyzer and ferritin level was estimated by using VIDAS automated quantitative test. While (S. Iron, TIBC) was estimated according to coloration method. The results shows significant decrease (p≤0.05) in Hb, PCV, S. iron and significant increase (p≤0.05) in ferritin while no changes occurs in RBC, WBC and TIBC compared with healthy women. In conclusion, blood parameters and Iron status have significant changes in osteoporosis women in Basra province / Iraq.

Keywords: osteoporosis, blood parameters, Iron status, hemoglobin, DEXA.