Abstract

A COMPREHENSIVE REVIEW ON NOVEL ANTIDIABETIC AND ANTIHYPERTENSIVE DRUGS

Samrin Khalfe* and Priyanka Kole*

Abstract

Diabetes mellitus is a common form of metabolic disorder where level of blood glucose in the blood stream raises high, because of deficiency of insulin and development of insulin resistance in diabetic individuals. It is categorize under modern age life style disorder, commonly affected by middle-aged people and the children in adolescents in most developed countries. Diabetic patients develop serious complication with the development of disease, such as obesity, risk of stroke and heart failure. Globally antidiabetic drugs formulate the second-largest market by sales in the pharmaceuticals industry after cancer. Various novel targets have identified and recently various therapeutic leads successfully completed their different phases of clinical trials such as GLP-1 agonist, DPP-IV inhibitors, SGLT2 inhibitors, and are going to be the next generation therapy for management of diabetes. Hypertension is the medical term for high blood pressure. It is dangerous because it makes the heart work too hard and contributes to atherosclerosis (hardening of arteries), besides increasing the risk of heart disease and stroke. HTN can also lead to other conditions such as congestive heart failure, kidney disease and blindness. Conventional antihypertensives are usually associated with many side effects. About 75 to 80% of the world population use herbal medicines, mainly in developing countries, for primary health care because of their better acceptability with human body and lesser side effects.

Keywords: Diabetes, GLP1 agonist, DPP4 Inhibitors, SGLT2 Inhibitors, Hypertension, Herbal drugs, Antihypertensive, Atherosclerosis.